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This job was posted by https://www.kansasworks.com : For more information, please see: https://www.kansasworks.com/jobs/12934348

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rPost Doctoral Fellow - Internal Medicine (Endocrinology, Diabetes, & Clinical Pharmacology)

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Department:

SOM KC Internal Medicine - Endocrinology, Metabolism & Genetics

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Diabetes Institute

Position Title:

Post Doctoral Fellow - Internal Medicine (Endocrinology, Diabetes, & Clinical Pharmacology)

Job Family Group:

Professional Staff

Job Description Summary:

A postdoctoral position is available in the laboratory of Andrew Lutkewitte, Assistant Professor in the Division of Endocrinology, Diabetes, and Clinical Pharmacology. Our research program seeks to increase our understanding of metabolic crosstalk between tissues in the context of obesity. This specific project aims to establish the mechanistic links between adipose tissue dysfunction and dysregulated hepatic metabolism. This project will use comprehensive metabolic testing combined with multi-omic approaches to assess the signaling mechanisms that drive hepatic de novo lipogenesis following adipose dysfunction. We have established several mouse models of adipose tissue dysfunction and loss; in addition, we use several in vitro cell lines and primary hepatocytes and adipocytes to study the molecular mechanism in controlled conditions using radio and isotopic tracing methods. Additional projects in the lab include identifying molecular mechanisms controlling adipose tissue triglyceride synthesis. If interested, please send a letter describing your research experience/interest/future career aspirations, CV, and contact information for three references.

Postdoctoral scholars at the University of Kansas Medical Center are individuals who have received their terminal degree and who have opted to pursue further training in a postdoctoral appointment. Postdoctoral scholarship is a time-limited appointment, the primary purpose of which is to provide research and/or scholarly training for an academic or research career.

Job Description:

Required Qualifications

Education: Ph.D. or equivalent in the field of metabolism with 4 years of research experience

Work Experience: Prior experience with human/mouse biospecimen processing, animal husbandry and colony management and cell culture.

Skills:

• Must have the ability to plan, organize, and work as part of an interactive team.
• Experimental design, implementation, and analysis. General research methods include pipetting, centrifugation, and reagent handling.

Preferred Qualifications

Skills:

• Proficiency with routine biochemical techniques, molecular biology, immunohistochemistry, sterile cell culture, DNA, RNA and protein-based assays. Additionally, experience in animal handling and metabolic analysis, dissection, and downstream tissue analyses. Finally, experience working with mouse models of metabolic disease.
• Demonstrated ability to run multiple independent projects and competing priorities simultaneously.
• Need to have good communication skills and prepare presentations for lab meetings and local conferences.
• Experience with analysis of large data sets include RNA seq and Proteomics.

Job Duties

• Lead projects related to adipose tissue-liver crosstalk using multiple mouse models.
• Perform experiments using cell culture to understand mechanisms underlying obesity-related metabolic disease. Experiments will involve primary cell culture, biochemistry, molecular biology assays, techniques such as immunoblotting, and qPCR etc.
• Perform experiments independently and as a team using animal models of obesity and fatty-liver disease.
• Metabolic assessment of animal models using indirect c lorimetry, BioDaq food intake monitoring system, Echo MRI, and other methods such as insulin/glucose tolerance testing.
• Facilitate studies using adeno-associated viral expression of metabolic genes in vivo.
• Isolation of primary cells from mouse tissues (adipose, liver).
• Design new experimental plan independently in consultation with the supervisor.
• Apply for postdoctoral research grants/ travel awards.
• Attend and present at weekly research and study team meetings as well as national/international meetings.

Required Documents

• Resume/CV
• Cover letter

Comprehensive Benefits Package:

Coverage begins on day one for health, dental, and vision insurance and includes health expense accounts with generous employer contributions if the employee participates in a qualifying health plan. Employer-paid life insurance, long-term disability insurance, and various additional voluntary insurance plans are available. Paid time off, including vacation and sick, begins accruing upon hire, plus ten paid holidays. One paid discretionary day is available after six months of employment, and paid time off for bereavement, jury duty, military service, and parental leave is a